Association of a protective paraoxonase 1 (PON1) polymorphism in Parkinson's disease.

doi:10.1016/j.neulet.2012.06.007

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Article

Association of a protective paraoxonase 1 (PON1) polymorphism in Parkinson's disease.

Neuroscience letters - 26 Jul 2012

Belin Andrea Carmine, Ran Caroline, Anvret Anna, Paddock Silvia, Westerlund Marie, Håkansson Anna, Nissbrandt Hans, Söderkvist Peter, Dizdar Nil, Ahmadi Ahmad, Anvret Maria, Willows Thomas, Sydow Olof, Galter Dagmar

Abstract excerpt

Pesticide exposure has been suggested to increase the risk to develop Parkinson's disease (PD). The arylesterase paraoxonase 1 (PON1) is mainly expressed in the liver and hydrolyzes organophosphates such as pesticides. The polymorphism Leu54Met (rs854560) in PON1, impairing enzyme activity and leading to decreased PON1 expression levels, has been reported to be associated with Parkinson's disease (PD). PON1 is...

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Identifiers

PMID: 22704918
DOI: 10.1016/j.neulet.2012.06.007

Genes

PON1
PON2
PON3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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