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Role of PON1 L55M Gene Polymorphism in Parkinson's Disease among North Indian Population.

Neurology India - 1 Mar 2024

Kumar Brijesh, Saluja Alvee, Juneja Abhishek, Anand Kuljeet S, Saraswathy Kallur N, Longkumer Imnameren, Dhamija Rajinder K

Abstract excerpt

BACKGROUND AND OBJECTIVES: The role of various genetic markers including alpha synuclein, Parkin, etc., is known in the pathogenesis of Parkinson's disease (PD). Novel genetic markers including paraoxonase 1 (PON1) have also been linked to PD pathogenesis in recent studies. The PON1 L55M allele carriers may have defective clearance of environmental toxins and may result in increased susceptibility to PD. Hence,...

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PMID: 38691483
DOI: 10.4103/neuroindia.NI_596_20

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