Article
A triallelic Fc gamma receptor type IIIA polymorphism influences the binding of human IgG by NK cell Fc gamma RIIIa.
Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 1996
de Haas M, Koene H R, Kleijer M, de Vries E, Simsek S, van Tol M J, Roos D, von dem Borne A E
Abstract excerpt
A donor-dependent difference in electrophoretic mobility of deglycosylated released Fc gamma RIIIa derived from NK cells and macrophages was observed. We investigated whether this was based on a polymorphism of the Fc gamma RIIIA gene. Cloning and sequencing of Fc gamma RIIIa-encoding cDNA derived from an apparently heterozygous donor showed one single nucleotide substitution at position 230 (T-->G), which was...
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