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Article

Fc gamma receptor III on human neutrophils. Allelic variants have functionally distinct capacities.

The Journal of clinical investigation - 1 Apr 1990

Salmon J E, Edberg J C, Kimberly R P

Abstract excerpt

As a model system to explore the functional consequences of structural variants of human Fc gamma receptors (Fc gamma R), we have investigated Fc gamma R-mediated phagocytosis in relation to the NA1-NA2 polymorphism of Fc gamma RIII (CD16) on neutrophils (Fc gamma RIIIPMN). The neutrophil-specific NA antigen system is a biallelic polymorphism with codominant expression demonstrating a gene dose effect with the...

Topics

Adult
Alleles
Antigens, Differentiation
Antigens, Surface
Epitopes
Humans
Isoantigens
Middle Aged
Neutrophils
Phagocytosis
Polymorphism, Genetic
Receptors, Fc

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, IgG

Structure-Activity Relationship

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Identifiers

PMID: 1690757
DOI: 10.1172/JCI114566
PMCID: PMC296565

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1690757-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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