Article
A single amino acid in the second Ig-like domain of the human Fc gamma receptor II is critical for human IgG2 binding.
Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 1991
Warmerdam P A, van de Winkel J G, Vlug A, Westerdaal N A, Capel P J
Abstract excerpt
The low-affinity human Fc gamma RIIa is encoded by a single gene with allelic variation, defined by low-responder and high-responder alleles (LR and HR). The HR Fc gamma RIIa transcript interacts strongly with murine (m) IgG1 complexes, in contrast to the LR Fc gamma RIIa. Furthermore, the transcripts can be discriminated by mAb 41H16, which recognizes an epitope expressed on the HR Fc gamma RIIa molecule. We...
Topics
- Alleles
- Amino Acids
- Animals
- Antigens, Differentiation
- Binding Sites
- Humans
- Immunoglobulin G
- Mice
- Polymorphism, Genetic
- Receptors, Fc
- Receptors, IgG