Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans.

doi:10.1172/JCI118552

Article

Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans.

The Journal of clinical investigation - 1 Mar 1996

Salmon J E, Millard S, Schachter L A, Arnett F C, Ginzler E M, Gourley M F, Ramsey-Goldman R, Peterson M G, Kimberly R P

Abstract excerpt

Allelic variants of Fc gamma R confer distinct phagocytic capacities providing a mechanism for heritable susceptibility to immune complex disease. Human Fc gamma RIIa has two codominantly expressed alleles, R131 and H131, which differ substantially in their ability to ligate human IgG2. The Fc ga...

Topics

Alleles
Black People
Humans
Lupus Erythematosus, Systemic
Lupus Nephritis
Pilot Projects
Receptors, IgG
Risk Factors
Black or African American

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