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Article

Meningococcal disease and polymorphism of FcγRIIa (CD32) in late complement component-deficient individuals

1 Jan 1998

Abstract excerpt

Late complement component-deficient (LCCD) individuals lack plasma bactericidal activity and are highly susceptible to meningococcal disease. Phagocytosis plays a significant role in immune defence against meningococci and involves FcgammaRIIa (CD32) on leucocytes. Two allotypic forms are currently recognized: FcgammaRIIa-R131 and RIIa-H131. Neutrophils with the IIa-H/H131 allotype are more effective in...

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PMID: 9472667
DOI: 10.1046/j.1365-2249.1998.00484.x

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