Article
Comparative studies of the long-term growth of lymphocytes from tumor infiltrates, tumor-draining lymph nodes, and peripheral blood by repeated in vitro stimulation with autologous tumor.
Journal of biological response modifiers - 1 Aug 1990
Skornick Y, Topalian S, Rosenberg S A
Abstract excerpt
Tumor-infiltrating lymphocytes (TILs) have been grown from a variety of human tumors. TILs from some patients with melanoma demonstrate lytic activity specific for autologous tumor, and can mediate tumor regression when adoptively transferred to select cancer patients. In this study, we have compared the in vitro properties of lymphocytes from peripheral blood (PBLs), from draining lymph nodes (DLNs), and from...
Topics
- Adolescent
- Adult
- Cell Division
- Cells, Cultured
- Culture Media
- Cytotoxicity Tests, Immunologic
- Female
- Humans
- Interleukin-2
- Lymph Nodes
- Lymphocytes