Article
Generation of cytotoxic effector cells against human melanoma.
Cancer immunology, immunotherapy : CII - 1 Jun 1995
Leong S P, Zhou Y M, Granberry M E, Wang T F, Grogan T M, Spier C, White R, Mehta A, Lin A Y
Abstract excerpt
Metastatic or tumor-draining lymph nodes from six of nine melanoma patients undergoing lymph node dissection for metastatic melanoma generated cytotoxic T cells against autologous melanoma when these lymph node cells were treated by in vitro sensitization and recombinant interleukin-2 (IL-2). During the initial lymphocyte culture (2-6 weeks), cross-reactivity with autologous tumor cells, K562 and Daudi cells was...
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