Article
Generation of cytotoxic effector cells against human melanoma.
Cancer immunology, immunotherapy : CII - 1 Jun 1995
Leong S P, Zhou Y M, Granberry M E, Wang T F, Grogan T M, Spier C, White R, Mehta A, Lin A Y
Abstract excerpt
Metastatic or tumor-draining lymph nodes from six of nine melanoma patients undergoing lymph node dissection for metastatic melanoma generated cytotoxic T cells against autologous melanoma when these lymph node cells were treated by in vitro sensitization and recombinant interleukin-2 (IL-2). Dur...
Topics
- Adult
- Aged
- Cell Division
- Cytotoxicity, Immunologic
- Dose-Response Relationship, Drug
- Female
- HLA Antigens
- Histocompatibility Antigens Class I
- Histocompatibility Antigens Class II
- Humans
- Immunization
- Immunotherapy, Adoptive
- Interleukin-2
- Lymph Nodes
- Lymphatic Metastasis