Limited antitumor T cell response in melanoma patients vaccinated with interleukin-2 gene-transduced allogeneic melanoma cells.

doi:10.1089/hum.1996.7.16-1955

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Article

Limited antitumor T cell response in melanoma patients vaccinated with interleukin-2 gene-transduced allogeneic melanoma cells.

Human gene therapy - 20 Oct 1996

Arienti F, Sulé-Suso J, Belli F, Mascheroni L, Rivoltini L, Melani C, Maio M, Cascinelli N, Colombo M P, Parmiani G

Abstract excerpt

We have immunized advanced melanoma patients with a HLA-A2-compatible human melanoma line genetically modified to release interleukin-2 (IL-2), to elicit or increase a T cell-mediated anti-melanoma response that may affect distant lesions. Twelve stage-IV patients were injected subcutaneously at...

Topics

Adult
Aged
Antibodies
Antigens, Neoplasm
Cell Line, Transformed
Cell Transplantation
Cytotoxicity Tests, Immunologic
Female
Genetic Therapy
HLA-A2 Antigen
Humans
Interleukin-2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Isoantigens

Leukocytes, Mononuclear

Male

Melanoma

Middle Aged

Phenotype

Source

Open in PubMed

Identifiers

PMID: 8930655
DOI: 10.1089/hum.1996.7.16-1955

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8930655-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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