Tumour-infiltrating lymphocytes in primary melanoma: functional consequences of differential IL-2 receptor expression.

doi:10.1111/j.1365-2249.1993.tb03365.x

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Article

Tumour-infiltrating lymphocytes in primary melanoma: functional consequences of differential IL-2 receptor expression.

Clinical and experimental immunology - 1 Jan 1993

Becker J C, Schwinn A, Dummer R, Burg G, Bröcker E B

Abstract excerpt

Tumour-infiltrating lymphocytes (TIL) have been isolated from early primary melanoma (Clark level III) and expanded in vitro using culture conditions with low concentrations of IL-2 (50 U/ml). Immediately after isolation TIL consisted of mainly CD3+ T cells, and the portion of CD56+ natural kille...

Topics

Antigens, CD
Antigens, Differentiation, T-Lymphocyte
CD56 Antigen
Cytotoxicity, Immunologic
Humans
Lymphocytes, Tumor-Infiltrating
Melanoma
Phenotype
Receptors, Interleukin-2
Tumor Cells, Cultured

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