Article
Tumour-infiltrating lymphocytes in primary melanoma: functional consequences of differential IL-2 receptor expression.
Clinical and experimental immunology - 1 Jan 1993
Becker J C, Schwinn A, Dummer R, Burg G, Bröcker E B
Abstract excerpt
Tumour-infiltrating lymphocytes (TIL) have been isolated from early primary melanoma (Clark level III) and expanded in vitro using culture conditions with low concentrations of IL-2 (50 U/ml). Immediately after isolation TIL consisted of mainly CD3+ T cells, and the portion of CD56+ natural killer (NK) cells was below 20%. Fresh TIL cultures could be distinguished by CD25 expression since some contained up to...
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