Characterization and augmentation of CD4+ cytotoxic T cell lines against melanoma.

doi:10.1007/BF01533383

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Article

Characterization and augmentation of CD4+ cytotoxic T cell lines against melanoma.

Cancer immunology, immunotherapy : CII - 1 Sept 1994

Morisaki T, Morton D L, Uchiyama A, Yuzuki D, Barth A, Hoon D S

Abstract excerpt

Cytotoxic T cells have been implicated in the control of the progression of human melanoma. Most studies on human tumor T cell immunity have focused on the CD3+CD8+ cytotoxic T lymphocyte (CTL) phenotype; however, CD3+CD4+ CTL are important effector cells in other diseases and may also contribute to antimelanoma immunity. In this study we compared the functional activity of CD3+CD4+ and CD3+CD8+ CTL lines...

Topics

Base Sequence
CD4-CD8 Ratio
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Cell Adhesion
Cell Division
Cytokines
Cytotoxicity, Immunologic
Esterases
Humans
Immunotherapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interleukin-2

Interleukin-4

Melanoma

Molecular Sequence Data

Phenotype

Receptors, Cytokine

Tumor Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 7923247
DOI: 10.1007/BF01533383
PMCID: PMC11038744

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7923247-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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