Article
Selective silencing of full-length CD80 but not IgV-CD80 leads to impaired clonal deletion of self-reactive T cells and altered regulation of immune responses.
European journal of immunology - 1 Jan 2001
Bugeon L, Hargreaves R E, Crompton T, Outram S, Rahemtulla A, Porter A C, Dallman M J
Abstract excerpt
Co-stimulation provided by the B7 family of proteins underpins the development of protective immunity. There are three identified members of this family: CD80, its splice variant IgV-CD80 and CD86. It has hitherto been difficult to analyze the expression and function of IgV-CD80 since there are no appropriate reagents capable of distinguishing it from CD80. We have generated mice, by gene targeting, the lack CD80...
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