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Article

Batf3 selectively determines acquisition of CD8+ dendritic cell phenotype and function.

Immunology and cell biology - 1 Feb 2017

Chandra Janin, Kuo Paula T Y, Hahn Anne M, Belz Gabrielle T, Frazer Ian H

Abstract excerpt

Batf3 is a transcription factor that impacts the development of CD103+ tissue-resident dendritic cells (DCs). However, whether Batf3 is absolutely required for the development of CD8+ DCs remains controversial. Id2 is required for CD8+ DC development. Here we show that bone marrow chimeric mice with a deletion of Id2 in the CD11c compartment lose the ability to reject a skin graft expressing a non-self protein...

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Identifiers

PMID: 27897162
DOI: 10.1038/icb.2016.83
PMCID: PMC5309136

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