Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Growth retardation and dyslymphopoiesis accompanied by G2/M arrest in APEX2-null mice

19 Aug 2004

Abstract excerpt

APEX2/APE2 is a secondary mammalian apurinic/apyrimidinic endonuclease that associates with proliferating cell nuclear antigen (PCNA), and the progression of S phase of the cell cycle is accompanied by its expression. To determine the biologic significance of APEX2, we established APEX2-null mice. These mice were about 80% the size of their wild-type littermates and exhibited a moderate dyshematopoiesis and a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to Immune Cell Function and Interaction
Share to Polyomavirus and related diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15319281
DOI: 10.1182/blood-2004-04-1476

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Growth retardation and dyslymphopoiesis accompanied by G2/M arrest in APEX2-null micePMID 15319281Read ↗

Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genesSemantic proximity Read ↗

E2F1 and E2F2 determine thresholds for antigen-induced T-cell proliferation and suppress tumorigenesis.Semantic proximity Read ↗

APE1 deficiency promotes cellular senescence and premature aging featuresSemantic proximity Read ↗

The E-Id Protein Axis Specifies Adaptive Lymphoid Cell Identity and Suppresses Thymic Innate Lymphoid Cell Development.Semantic proximity Read ↗

Early-onset lymphoma and extensive embryonic apoptosis in two domain-specific Fen1 mice mutants.Semantic proximity Read ↗

Apex1 safeguards genomic stability to ensure a cytopathic T cell fate in autoimmune disease modelsSemantic proximity Read ↗

E2A proteins enforce a proliferation checkpoint in developing thymocytes.Semantic proximity Read ↗

High incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout mice.Semantic proximity Read ↗

APE2 Promotes AID-Dependent Somatic Hypermutation in Primary B Cell Cultures That Is Suppressed by APE1.Semantic proximity Read ↗

TRIB2 regulates normal and stress-induced thymocyte proliferationSemantic proximity Read ↗

E2A Deficiency Leads to Abnormalities in αβ T-Cell Development and to Rapid Development of T-Cell LymphomasSemantic proximity Read ↗

Human Ape2 protein has a 3'-5' exonuclease activity that acts preferentially on mismatched base pairs.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.