Article
Human Ape2 protein has a 3'-5' exonuclease activity that acts preferentially on mismatched base pairs.
Nucleic acids research - 1 Jan 2006
Burkovics Peter, Szukacsov Valeria, Unk Ildiko, Haracska Lajos
Abstract excerpt
DNA damage, such as abasic sites and DNA strand breaks with 3'-phosphate and 3'-phosphoglycolate termini present cytotoxic and mutagenic threats to the cell. Class II AP endonucleases play a major role in the repair of abasic sites as well as of 3'-modified termini. Human cells contain two class II AP endonucleases, the Ape1 and Ape2 proteins. Ape1 possesses a strong AP-endonuclease activity and weak...
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