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Apex1 safeguards genomic stability to ensure a cytopathic T cell fate in autoimmune disease models

31 Dec 2024

Abstract excerpt

T cells have a remarkable capacity to clonally expand, a process that is intricately linked to their effector activities. As vigorously proliferating T cell also incur substantial DNA lesions, how the dividing T cells safeguard their genomic integrity to allow the generation of T effector cells remains largely unknown. Here we report the identification of the apurinic/apyrimidinic endonuclease-1 (Apex1) as an...

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PMID: 39739423
DOI: 10.1172/jci183671

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