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Article

Early-onset lymphoma and extensive embryonic apoptosis in two domain-specific Fen1 mice mutants.

Cancer research - 15 Jun 2008

Larsen Elisabeth, Kleppa Liv, Meza Trine J, Meza-Zepeda Leonardo A, Rada Christina, Castellanos Cesilie G, Lien Guro F, Nesse Gaute J, Neuberger Michael S, Laerdahl Jon K, William Doughty Richard, Klungland Arne

Abstract excerpt

Flap endonuclease 1 (FEN1) processes Okazaki fragments in lagging strand DNA synthesis, and FEN1 is involved in several DNA repair pathways. The interaction of FEN1 with the proliferating cell nuclear antigen (PCNA) processivity factor is central to the function of FEN1 in both DNA replication and repair. Here we present two gene-targeted mice with mutations in FEN1. The first mutant mouse carries a single amino...

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Source

Identifiers

PMID: 18559501
DOI: 10.1158/0008-5472.CAN-08-0168

Genes

FEN1
PCNA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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