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Article

SOS response induction by beta-lactams and bacterial defense against antibiotic lethality.

Science (New York, N.Y.) - 10 Sept 2004

Miller Christine, Thomsen Line Elnif, Gaggero Carina, Mosseri Ronen, Ingmer Hanne, Cohen Stanley N

Abstract excerpt

The SOS response aids bacterial propagation by inhibiting cell division during repair of DNA damage. We report that inactivation of the ftsI gene product, penicillin binding protein 3, by either beta-lactam antibiotics or genetic mutation induces SOS in Escherichia coli through the DpiBA two-component signal transduction system. This event, which requires the SOS-promoting recA and lexA genes as well as dpiA,...

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Source

Identifiers

PMID: 15308764
DOI: 10.1126/science.1101630

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SOS response induction by beta-lactams and bacterial defense against antibiotic lethality.PMID 15308764Read ↗

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