Article
Novel inhibitors of bacterial cytokinesis identified by a cell-based antibiotic screening assay.
The Journal of biological chemistry - 2 Dec 2005
Stokes Neil R, Sievers Jörg, Barker Stephanie, Bennett James M, Brown David R, Collins Ian, Errington Veronica M, Foulger David, Hall Michelle, Halsey Rowena, Johnson Hazel, Rose Valerie, Thomaides Helena B, Haydon David J, Czaplewski Lloyd G, Errington Jeff
Abstract excerpt
The continuous emergence of antibiotic resistance demands that novel classes of antibiotics continue to be developed. The division machinery of bacteria is an attractive target because it comprises seven or more essential proteins that are conserved almost throughout the bacteria but are absent from humans. We describe the development of a cell-based assay for inhibitors of cell division and its use to isolate a...
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