Article

Boronic acid derivative inhibits LexA mediated SOS response in Mycobacteria

2023-11-15

Abstract excerpt

Antimicrobial resistance (AMR) properties of several pathogens pose as one of the major global concerns demanding continuous innovation in order to be controlled. The bacterial “SOS” response, regulated by LexA and RecA, contributes to AMR through advantageous mutations. Therefore, targeting LexA/RecA system with a novel inhibitor could suppress “SOS” response and may reduce AMR. However, RecA presents a challenge...

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Literature Corpus work: 56f1378c-91f9-5ab8-b38f-9a3da65e165b
DOI: 10.1101/2023.11.15.567215

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