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Article

Zinc blocks SOS-induced antibiotic resistance via inhibition of RecA in Escherichia coli.

PloS one - 1 Jan 2017

Bunnell Bryan E, Escobar Jillian F, Bair Kirsten L, Sutton Mark D, Crane John K

Abstract excerpt

Zinc inhibits the virulence of diarrheagenic E. coli by inducing the envelope stress response and inhibiting the SOS response. The SOS response is triggered by damage to bacterial DNA. In Shiga-toxigenic E. coli, the SOS response strongly induces the production of Shiga toxins (Stx) and of the bacteriophages that encode the Stx genes. In E. coli, induction of the SOS response is accompanied by a higher mutation...

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Share to Anti-Bacterial Agents
Share to Drug Resistance, Microbial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Escherichia coli

Share to Gene Expression Regulation, Bacterial

Share to Rec A Recombinases

Share to SOS Response, Genetics

Share to Virulence

Source

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Identifiers

PMID: 28542496
DOI: 10.1371/journal.pone.0178303
PMCID: PMC5440055

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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