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Article

Functional changes in temperature-sensitive mutants of the adenovirus single-stranded DNA-binding protein are accompanied by structural alterations.

Journal of virology - 1 Jan 1992

Tsuji M, Kitchingman G R

Abstract excerpt

Adenovirus requires the virus-encoded single-stranded DNA-binding protein (DBP) to replicate its DNA. We have previously shown (M. Tsuji, P. C. van der Vliet, and G. R. Kitchingman, J. Biol. Chem. 266:16178-16187, 1991) that the inability of three temperature-sensitive (ts) mutant DBPs (Ad2+ ND1ts23, Ad2ts111A, and Ad5ts125) to support DNA replication at the nonpermissive temperature was associated with impaired...

Topics

Adenoviridae
Adenovirus E2 Proteins
Antibodies, Monoclonal
Cell Line
DNA, Single-Stranded
DNA, Viral
DNA-Binding Proteins
Endopeptidases
Microscopy, Electron
Mutation
Temperature

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Viral Proteins

Zinc

Source

Open in PubMed Open full text

Identifiers

PMID: 1530772
DOI: 10.1128/JVI.66.1.480-488.1992
PMCID: PMC238308

Genes

DBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1530772-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Functional changes in temperature-sensitive mutants of the adenovirus single-stranded DNA-binding protein are accompanied by structural alterations.PMID 1530772Read ↗

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