Temperature-sensitive mutants of adenovirus single-stranded DNA-binding protein. Inability to support DNA replication is associated with an altered DNA-binding activity of the protein.

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Article

Temperature-sensitive mutants of adenovirus single-stranded DNA-binding protein. Inability to support DNA replication is associated with an altered DNA-binding activity of the protein.

The Journal of biological chemistry - 25 Aug 1991

Tsuji M, van der Vliet P C, Kitchingman G R

Abstract excerpt

The adenovirus single-stranded DNA-binding protein (DBP) is an essential factor in viral DNA replication. Three temperature-sensitive (ts) adenoviruses (Ad2+ND1ts23, Ad2ts111A, and Ad5ts125) are known to have single amino acid substitutions in their DBPs that result in defective DNA replication a...

Topics

Adenoviridae
Adenovirus E2 Proteins
Blotting, Western
Chromatography, Liquid
DNA Replication
DNA, Single-Stranded
DNA, Viral
DNA-Binding Proteins
Electrophoresis, Polyacrylamide Gel
Genes, Viral
Kinetics
Mutation
Temperature
Viral Proteins

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Open in PubMed

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PMID: 1831456

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1831456-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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