The phenotype in vitro and in infected cells of herpes simplex virus 1 alpha trans-inducing factor (VP16) carrying temperature-sensitive mutations introduced by substitution of cysteines.

doi:10.1128/JVI.69.12.7658-7667.1995

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Article

The phenotype in vitro and in infected cells of herpes simplex virus 1 alpha trans-inducing factor (VP16) carrying temperature-sensitive mutations introduced by substitution of cysteines.

Journal of virology - 1 Dec 1995

Poon A P, Roizman B

Abstract excerpt

alpha trans-inducing factor (alpha TIF, VP16, Vmw65) is an essential structural protein of herpes simplex virus, being required for virion assembly. The protein also forms complexes with host proteins and a response element and transactivates the alpha genes which carry this element. The protein contains an acidic carboxyl terminus required for transactivation and a much larger amino-terminal domain required for...

Topics

Animals
Autoradiography
Base Sequence
Cells, Cultured
Chickens
Chlorocebus aethiops
Cysteine
Herpes Simplex Virus Protein Vmw65
Herpesvirus 1, Human
Humans
Methionine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutagenesis

Ovalbumin

Phenotype

Plasmids

Point Mutation

Promoter Regions, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 7494274
DOI: 10.1128/JVI.69.12.7658-7667.1995
PMCID: PMC189706

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7494274-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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