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Article

GANP-mediated recruitment of activation-induced cytidine deaminase to cell nuclei and to immunoglobulin variable region DNA.

The Journal of biological chemistry - 30 Jul 2010

Maeda Kazuhiko, Singh Shailendra Kumar, Eda Kazufumi, Kitabatake Masahiro, Pham Phuong, Goodman Myron F, Sakaguchi Nobuo

Abstract excerpt

AID (activation-induced cytidine deaminase) catalyzes transcription-dependent deamination of C --> U in immunoglobulin variable (IgV) regions to initiate somatic hypermutation (SHM) in germinal center B-cells. SHM is essential in generating high affinity antibodies. Here we show that when coexpressed with GANP (germinal center-associated nuclear protein) in COS-7 cells, AID is transported from the cytoplasm and...

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Identifiers

PMID: 20507984
DOI: 10.1074/jbc.M110.131441
PMCID: PMC2911284

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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GANP-mediated recruitment of activation-induced cytidine deaminase to cell nuclei and to immunoglobulin variable region DNA.PMID 20507984Read ↗

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