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Article

Glutathione S-transferase genotype GSTM1 as a predictor of elevated angiogenic phenotype in patients with early onset breast cancer.

Angiogenesis - 1 Jan 2004

Medeiros Rui, Soares Raquel, Vasconcelos André, Schmitt Fernando, Lopes Carlos

Abstract excerpt

The genes coding for separate isoforms of both the human glutathione-S-transferase class (GST) mu and class theta enzymes (GSTM1 and GSTT1) are polymorphic with a percentage of normal individuals exhibiting a homozygous deletion of the genes. An association between glutathione, proliferation and tumour angiogenesis has been observed. The aim of the present study was to analyse GST polymorphisms and to determine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15302996
DOI: 10.1023/B:AGEN.0000037330.20121.d8

Genes

GSTM1
GSTT1
MVD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Glutathione S-transferase genotype GSTM1 as a predictor of elevated angiogenic phenotype in patients with early onset breast cancer.PMID 15302996Read ↗

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Glutathione S-transferases deletions may act as prognosis and therapeutic markers in breast cancer.Semantic proximity Read ↗

Study of the frequencies of CYP1A1 gene polymorphisms and glutathione S-transferase mu1 gene in primary breast cancers: an update with an additional 114 cases.Semantic proximity Read ↗

Genetic polymorphisms and transcriptional pattern analysis of CYP1A1, AhR, GSTM1, GSTP1 and GSTT1 genes in breast cancer.Semantic proximity Read ↗

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Glutathione S-transferase M1 null genotype: lack of association with tumour characteristics and survival in advanced breast cancer.Semantic proximity Read ↗

Increased DNA alterations in atherosclerotic lesions of individuals lacking the GSTM1 genotype.Semantic proximity Read ↗

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