Glutathione S-transferase P1 c.313A > G polymorphism could be useful in the prediction of doxorubicin response in breast cancer patients.

doi:10.1093/annonc/mdr483

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Glutathione S-transferase P1 c.313A > G polymorphism could be useful in the prediction of doxorubicin response in breast cancer patients.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Jul 2012

Romero A, Martín M, Oliva B, de la Torre J, Furio V, de la Hoya M, García-Sáenz J A, Moreno A, Román J M, Diaz-Rubio E, Caldés T

Abstract excerpt

BACKGROUND: Identification of predicting factors for anthracyclines-based chemotherapy remains a clinical challenge. Glutathione S-transferase (GSTs) enzymes detoxify chemotherapy drugs and their metabolites. Several polymorphisms in GST genes result in reduced or no activity of the enzymes. Specifically, GSTM1 and GSTT1 genes are polymorphically deleted, the polymorphism GSTP1 c.313A>G (rs1695) determines the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibiotics, Antineoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Docetaxel

Share to Doxorubicin

Share to Drug Resistance, Neoplasm

Share to Glutathione S-Transferase pi

Share to Glutathione Transferase

Share to Multivariate Analysis

Share to Taxoids

Source

Open in PubMed

Identifiers

PMID: 22052985
DOI: 10.1093/annonc/mdr483

Genes

GSTP1
GSTA1
GSTM1
GSTT1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glutathione S-transferase P1 c.313A > G polymorphism could be useful in the prediction of doxorubicin response in breast cancer patients.PMID 22052985Read ↗

Pharmacogenetic influence of GST polymorphisms on anthracycline-based chemotherapy responses and toxicity in breast cancer patients: a multi-analytical approach.Semantic proximity Read ↗

Polymorphisms in genes involved in drug detoxification and clinical outcomes of anthracycline-based neoadjuvant chemotherapy in Chinese Han breast cancer patients.Semantic proximity Read ↗

GSTP1 c.313A > G mutation is an independent risk factor for neutropenia hematotoxicity induced by anthracycline-/paclitaxel-based chemotherapy in breast cancer patients.Semantic proximity Read ↗

Drug-metabolizing enzyme polymorphisms predict clinical outcome in a node-positive breast cancer cohort.Semantic proximity Read ↗

DNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment responseSemantic proximity Read ↗

GSTT1, GSTM1, and GSTP1 polymorphisms as a prognostic factor in women with breast cancer.Semantic proximity Read ↗

Platinum/paclitaxel-based chemotherapy in advanced ovarian carcinoma: glutathione S-transferase genetic polymorphisms as predictive biomarkers of disease outcome.Semantic proximity Read ↗

Polymorphisms of GSTP1 is associated with differences of chemotherapy response and toxicity in breast cancer.Semantic proximity Read ↗

GSTP1, GSTM1, and GSTT1 polymorphisms as predictors of response to chemotherapy in patients with breast cancer: a meta-analysis.Semantic proximity Read ↗

Genetic variants in oxidative stress-related genes predict chemoresistance in primary breast cancer: a prospective observational study and validation.Semantic proximity Read ↗

ABCB1 and GST polymorphisms associated with TP53 status in breast cancer.Semantic proximity Read ↗

Genetic polymorphisms and response to 5-fluorouracil, doxorubicin and cyclophosphamide chemotherapy in breast cancer patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.