Article
The GSTT1 polymorphism of the glutathione S-transferase system in the intratumoral microvessel density of breast cancer patients.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Oct 2010
Lourenço Gustavo J, Schenka André A, Cardoso-Filho Cassio, Pinto Glauce A, Costa-Gurgel Maria S, Vassallo José, Lima Carmen Silvia Passos
Abstract excerpt
It is well established that hypoxic microenvironment contributes to breast cancer progression by activation of transcriptional genes that promote angiogenesis. By promoting the antioxidant activity of glutathione, glutathione S-transferases (GSTs) are likely to facilitate the hypoxia-inducible factor-1α (HIF-1α) activity, therefore stimulating the angiogenesis. We investigated herein the influence of the GSTM1...
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