Article
Glutathione S-transferases deletions may act as prognosis and therapeutic markers in breast cancer.
Clinical and experimental medicine - 1 Feb 2018
Campos Clodoaldo Zago, Losi Guembarovski Roberta, de Oliveira Carlos Eduardo Coral, Banin Hirata Bruna Karina, Vitiello Glauco Akelinghton Freire, Dias Flávia Luísa, Hiroki Carlos Hiroji, Watanabe Maria Angelica Ehara, Mazzuco Tânia Longo
Abstract excerpt
Breast cancer (BC) is the main worldwide neoplasia in women. The metabolic balance between xenobiotic absorption and elimination rates plays an important role in preventing DNA damage and, consequently, tumor development. The glutathione S-transferases (GSTs), such as GSTM1 and GSTT1, and the NAD(P)H quinone oxidoreductase are important enzymes involved in phase II detoxification reactions. Deletions in GSTM1 and...
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