Article
A functional polymorphism in the promoter region of GSTM1 implies a complex role for GSTM1 in breast cancer.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 2009
Yu Ke-Da, Di Gen-Hong, Fan Lei, Wu Jiong, Hu Zhen, Shen Zhen-Zhou, Huang Wei, Shao Zhi-Ming
Abstract excerpt
Although a number of studies have been conducted to address the relation between a gene deletion polymorphism of glutathione S-transferase M1 (GSTM1) and breast cancer, no definite conclusion has been reached and no clear risk pattern has yet to emerge for GSTM1. We first conducted case-control studies that included 1920 subjects using a genotyping method allowing the definition of GSTM1-null (-/-), homozygous...
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