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Article

Increased DNA alterations in atherosclerotic lesions of individuals lacking the GSTM1 genotype.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Mar 2001

Izzotti A, Cartiglia C, Lewtas J, De Flora S

Abstract excerpt

Reduced glutathione (GSH) plays a critical role as an intracellular defense system providing detoxification of a broad spectrum of reactive species and their excretion as water-soluble conjugates. Conjugation of GSH with electrophiles is catalyzed by GSH S-transferases (GST), which constitute a broad family of phase II isoenzymes. Two of the GST encoding genes, GSTM1 (mu) and GSTT1 (theta), have a null genotype...

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Source

Identifiers

PMID: 11259393
DOI: 10.1096/fj.00-0312com

Genes

GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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