Article
Glutathione S-transferase M1 null genotype: lack of association with tumour characteristics and survival in advanced breast cancer.
Breast cancer research : BCR - 1 Jan 1999
Lizard-Nacol S, Coudert B, Colosetti P, Riedinger J M, Fargeot P, Brunet-Lecomte P
Abstract excerpt
BACKGROUND: Glutathione S-transferase (GST)M1, a member of the mu class GST gene family, has been shown to be polymorphic because of a partial gene deletion. This results in a failure to express the GSTM1 gene in 50-60% of individuals. Several studies have demonstrated a possible link with the GSTM1-null genotype and susceptibility to cancer. Furthermore, a GSTM1 isoenzyme has been positively associated with...
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