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Article

An apical MRCK-driven morphogenetic pathway controls epithelial polarity.

Nature cell biology - 1 Sept 2017

Zihni Ceniz, Vlassaks Evi, Terry Stephen, Carlton Jeremy, Leung Thomas King Chor, Olson Michael, Pichaud Franck, Balda Maria Susana, Matter Karl

Abstract excerpt

Polarized epithelia develop distinct cell surface domains, with the apical membrane acquiring characteristic morphological features such as microvilli. Cell polarization is driven by polarity determinants including the evolutionarily conserved partitioning-defective (PAR) proteins that are separated into distinct cortical domains. PAR protein segregation is thought to be a consequence of asymmetric actomyosin...

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PMID: 28825699
DOI: 10.1038/ncb3592
PMCID: PMC5617103

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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