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Article

The F-box protein Slmb restricts the activity of aPKC to polarize epithelial cells.

Development (Cambridge, England) - 1 Aug 2014

Skwarek Lara C, Windler Sarah L, de Vreede Geert, Rogers Gregory C, Bilder David

Abstract excerpt

The Par-3/Par-6/aPKC complex is the primary determinant of apical polarity in epithelia across animal species, but how the activity of this complex is restricted to allow polarization of the basolateral domain is less well understood. In Drosophila, several multiprotein modules antagonize the Par complex through a variety of means. Here we identify a new mechanism involving regulated protein degradation. Strong...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 25053431
DOI: 10.1242/dev.109694
PMCID: PMC4197664

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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