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Detection of mitochondrial DNA mutations using temporal temperature gradient gel electrophoresis.

Electrophoresis - 1 Aug 2004

Wong Lee-Jun C, Chen Tian-Jian, Tan Duan-Jun

Abstract excerpt

Mitochondrial disorders are a group of clinically and genetically heterogeneous diseases. Common recurrent mitochondrial DNA (mtDNA) point mutations account for the molecular defects of a small proportion of patients. In order to identify mtDNA mutations, comprehensive mutational analysis of the entire mitochondrial genome is necessary. We developed the temporal temperature gradient gel electrophoresis (TTGE)...

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PMID: 15300781
DOI: 10.1002/elps.200406016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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