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Article

Comprehensive scanning of the entire mitochondrial genome for mutations.

Clinical chemistry - 1 Nov 2002

Wong Lee-Jun C, Liang Min-Hui, Kwon Haeyoung, Park John, Bai Ren-Kui, Tan Duan-Jun

Abstract excerpt

BACKGROUND: Definitive molecular diagnosis of mitochondrial disorders has been greatly hindered by the tremendous clinical and genetic heterogeneity, the heteroplasmic condition of pathogenic mutations, and the presence of numerous homoplasmic mitochondrial DNA (mtDNA) variations with unknown significance. We used temporal temperature gradient gel electrophoresis (TTGE) to detect heteroplasmic mutations from...

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PMID: 12406974

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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