Article
Rapid detection of beta-globin gene mutations and polymorphisms by temporal temperature gradient gel electrophoresis.
Clinical chemistry - 1 May 2003
Shaji Ramachandran V, Edison Eunice Sindhuvi, Poonkuzhali Balasubramanian, Srivastava Alok, Chandy Mammen
Abstract excerpt
BACKGROUND: Inherited hemoglobin disorders represent the most common Mendelian disease worldwide. Prevention programs based on molecular diagnosis of heterozygous carriers and/or patients require the use of reliable mutation scanning methods in at-risk populations. METHODS: We developed a rapid and highly specific mutation-screening test based on temporal temperature gradient gel electrophoresis (TTGE). We...
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