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Article

The Fanconi anemia proteins functionally interact with the protein kinase regulated by RNA (PKR).

The Journal of biological chemistry - 15 Oct 2004

Zhang Xiaoling, Li June, Sejas Daniel P, Rathbun Keaney R, Bagby Grover C, Pang Qishen

Abstract excerpt

Protein kinase regulated by RNA (PKR) plays critical roles in cell growth and apoptosis and is implicated as a potential pathogenic factor of Alzheimer's, Parkinson's, and Huntington's diseases. Here we report that this proapoptotic kinase is also involved in Fanconi anemia (FA), a disease characterized by bone marrow (BM) failure and leukemia. We have used a BM extract to show that three FA proteins, FANCA,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enzyme Activation

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Source

Identifiers

PMID: 15299030
DOI: 10.1074/jbc.M403884200

Genes

FANCC
FANCA
FANCG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Fanconi anemia proteins functionally interact with the protein kinase regulated by RNA (PKR).PMID 15299030Read ↗

The anti-apoptotic function of Hsp70 in the interferon-inducible double-stranded RNA-dependent protein kinase-mediated death signaling pathway requires the Fanconi anemia protein, FANCC.Semantic proximity Read ↗

The protein-protein interaction landscape of Fanconi anemia protein A (FANCA) reveals its contributions to mRNA processesSemantic proximity Read ↗

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Aberrant Fanconi anaemia protein profiles in acute myeloid leukaemia cells.Semantic proximity Read ↗

The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR).Semantic proximity Read ↗

Clinical variability of Fanconi anemia (type C) results from expression of an amino terminal truncated Fanconi anemia complementation group C polypeptide with partial activity.Semantic proximity Read ↗

The Fanconi anemia protein FANCC binds to and facilitates the activation of STAT1 by gamma interferon and hematopoietic growth factors.Semantic proximity Read ↗

Fanconi anemia type C and p53 cooperate in apoptosis and tumorigenesis.Semantic proximity Read ↗

Fanconi anemia C gene product regulates expression of genes involved in differentiation and inflammation.Semantic proximity Read ↗

MxA overexpression reveals a common genetic link in four Fanconi anemia complementation groups.Semantic proximity Read ↗

Carboxy terminal region of the Fanconi anemia protein, FANCG/XRCC9, is required for functional activity.Semantic proximity Read ↗

The direct binding of the catalytic subunit of protein phosphatase 1 to the PKR protein kinase is necessary but not sufficient for inactivation and disruption of enzyme dimer formation.Semantic proximity Read ↗

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