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Article

The Fanconi anemia protein FANCC binds to and facilitates the activation of STAT1 by gamma interferon and hematopoietic growth factors.

Molecular and cellular biology - 1 Jul 2000

Pang Q, Fagerlie S, Christianson T A, Keeble W, Faulkner G, Diaz J, Rathbun R K, Bagby G C

Abstract excerpt

Hematopoietic progenitor cells from Fanconi anemia (FA) group C (FA-C) patients display hypersensitivity to the apoptotic effects of gamma interferon (IFN-gamma) and constitutively express a variety of IFN-dependent genes. Paradoxically, however, STAT1 activation is suppressed in IFN-stimulated FA cells, an abnormality corrected by transduction of normal FANCC cDNA. We therefore sought to define the specific role...

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Topics

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Share to Fanconi Anemia
Share to Fanconi Anemia Complementation Group Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Growth Substances

Share to Interferon gamma Receptor

Share to Interferon Regulatory Factor-1

Share to Janus Kinase 1

Share to Receptors, Interferon

Share to STAT1 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 10848598
DOI: 10.1128/MCB.20.13.4724-4735.2000
PMCID: PMC85895

Genes

STAT1
FANCC
JAK1
JAK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The Fanconi anemia protein FANCC binds to and facilitates the activation of STAT1 by gamma interferon and hematopoietic growth factors.PMID 10848598Read ↗

Functional correction of FA-C cells with FANCC suppresses the expression of interferon gamma-inducible genes.Semantic proximity Read ↗

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Recruitment of Stat4 to the Human Interferon-α/β Receptor Requires Activated Stat2Semantic proximity Read ↗

The anti-apoptotic function of Hsp70 in the interferon-inducible double-stranded RNA-dependent protein kinase-mediated death signaling pathway requires the Fanconi anemia protein, FANCC.Semantic proximity Read ↗

Signaling through a mutant IFN-gamma receptor.Semantic proximity Read ↗

Direct Association of STAT3 with the IFNAR-1 Chain of the Human Type I Interferon ReceptorSemantic proximity Read ↗

Repression of IL-4-Induced Gene Expression by IFN-γ Requires Stat1 ActivationSemantic proximity Read ↗

The Fanconi anemia proteins functionally interact with the protein kinase regulated by RNA (PKR).Semantic proximity Read ↗

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Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling.Semantic proximity Read ↗

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