Article
Fanconi anemia C gene product regulates expression of genes involved in differentiation and inflammation.
Oncogene - 24 Jun 2004
Zanier Romina, Briot Delphine, Dugas du Villard Jean-Antoine, Sarasin Alain, Rosselli Filippo
Abstract excerpt
Loss of Fanconi anemia (FA) proteins activity by recessive inherited mutations in one of the FA genes leads to a disease characterized by bone marrow failure, myeloid leukemia and DNA damage hypersensitivity. The aim of this work was to improve our understanding of the FA syndrome defining the transcription profile of the FA complementation group C (FANCC)-deficient cells in comparison to their ectopically...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Cell Cycle Proteins
- Cell Differentiation
- DNA Repair
- DNA-Binding Proteins
- Fanconi Anemia Complementation Group C Protein
- Fanconi Anemia Complementation Group Proteins
- Gene Expression
- Gene Expression Regulation
- Humans
- Inflammation
- Mutation
- Myeloid Cells