Article

The protein-protein interaction landscape of Fanconi anemia protein A (FANCA) reveals its contributions to mRNA processes

2025-09-12

Abstract excerpt

Fanconi Anemia (FA) is a rare inherited recessive disorder characterized by bone marrow failure, congenital abnormalities, and a predisposition to myeloid leukemia and some solid cancers. FA is caused by mutations in one of the 22 so-called FANC genes, with two thirds of FA patients being FANCA mutants. FANC proteins cooperate within the FANC/BRCA pathway, a DNA repair system essential for resolving DNA interstran...

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Literature Corpus work: f77b3d11-9998-593d-89ff-42a641acfc1f
DOI: 10.1101/2025.09.11.675346

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