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Article

Carboxy terminal region of the Fanconi anemia protein, FANCG/XRCC9, is required for functional activity.

Blood - 1 Sept 2000

Kuang Y, Garcia-Higuera I, Moran A, Mondoux M, Digweed M, D'Andrea A D

Abstract excerpt

Fanconi anemia (FA) is an autosomal recessive cancer susceptibility syndrome with eight complementation groups. Four of the FA genes have been cloned, and at least three of the encoded proteins, FANCA, FANCC, and FANCG/XRCC9, interact in a nuclear complex, required for the maintenance of normal chromosome stability. In the current study, mutant forms of the FANCA and FANCG proteins have been generated and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10961856

Genes

FANCG
FANCA
FANCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Carboxy terminal region of the Fanconi anemia protein, FANCG/XRCC9, is required for functional activity.PMID 10961856Read ↗

Functional analysis of patient-derived mutations in the Fanconi anemia gene, FANCG/XRCC9.Semantic proximity Read ↗

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Coordinate nuclear targeting of the FANCD2 and FANCI proteins via a FANCD2 nuclear localization signal.Semantic proximity Read ↗

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The molecular biology of Fanconi anemia.Semantic proximity Read ↗

Spectrum of mutations in the Fanconi anaemia group G gene, FANCG/XRCC9.Semantic proximity Read ↗

The Chinese hamster FANCG/XRCC9 mutant NM3 fails to express the monoubiquitinated form of the FANCD2 protein, is hypersensitive to a range of DNA damaging agents and exhibits a normal level of spontaneous sister chromatid exchange.Semantic proximity Read ↗

Genetic disruption of both Fancc and Fancg in mice recapitulates the hematopoietic manifestations of Fanconi anemia.Semantic proximity Read ↗

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