Article
Aberrant Fanconi anaemia protein profiles in acute myeloid leukaemia cells.
British journal of haematology - 1 Dec 2000
Xie Y, de Winter J P, Waisfisz Q, Nieuwint A W, Scheper R J, Arwert F, Hoatlin M E, Ossenkoppele G J, Schuurhuis G J, Joenje H
Abstract excerpt
Fanconi anaemia (FA) is an autosomal recessive disease strongly predisposing to bone marrow failure and acute myeloid leukaemia (AML). Four FA genes, corresponding to complementation groups A, C, F and G, have been cloned, but the molecular functions of the corresponding proteins are unknown. The high risk of AML in FA patients suggests that the 'FA pathway' helps to prevent AML in non-FA individuals. We examined...
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