Article
The anti-apoptotic function of Hsp70 in the interferon-inducible double-stranded RNA-dependent protein kinase-mediated death signaling pathway requires the Fanconi anemia protein, FANCC.
The Journal of biological chemistry - 20 Dec 2002
Pang Qishen, Christianson Tracy A, Keeble Winifred, Koretsky Tara, Bagby Grover C
Abstract excerpt
Proteins encoded by five of the six known Fanconi anemia (FA) genes form a heteromeric complex that facilitates repair of DNA damage induced by cross-linking agents. A certain number of these proteins, notably FANCC, also function independently to modulate apoptotic signaling, at least in part, by suppressing ground state activation of the pro-apoptotic interferon-inducible double-stranded RNA-dependent protein...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.