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Article

A hypomorphic mutation reveals a stringent requirement for the ATM checkpoint protein in telomere protection during early cell division in Drosophila.

G3 (Bethesda, Md.) - 21 Jun 2013

Morciano Patrizia, Zhang Yi, Cenci Giovanni, Rong Yikang S

Abstract excerpt

Using Drosophila as a model system, we identified a stringent requirement for the conserved function of Ataxia Telangiectasia Mutated (ATM) in telomere protection during early embryonic development. Animals homozygous for a hypomorphic mutation in atm develop normally with minimal telomere dysfunction. However, mutant females produce inviable embryos that succumb to mitotic failure caused by covalent fusions of...

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Identifiers

PMID: 23604076
DOI: 10.1534/g3.113.006312
PMCID: PMC3689801

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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