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Article

Mutational analysis reveals a role for the C terminus of the proteasome subunit Rpt4p in spindle pole body duplication in Saccharomyces cerevisiae.

Genetics - 1 Oct 2002

McDonald Heather B, Helfant Astrid Hoes, Mahony Erin M, Khosla Shaun K, Goetsch Loretta

Abstract excerpt

The ubiquitin/proteasome pathway plays a key role in regulating cell cycle progression. Previously, we reported that a conditional mutation in the Saccharomyces cerevisiae gene RPT4/PCS1, which encodes one of six ATPases in the proteasome 19S cap complex/regulatory particle (RP), causes failure of spindle pole body (SPB) duplication. To improve our understanding of Rpt4p, we created 58 new mutations, 53 of which...

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Identifiers

PMID: 12399382
DOI: 10.1093/genetics/162.2.705
PMCID: PMC1462277

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