Article
An in vivo structure-function study of armadillo, the beta-catenin homologue, reveals both separate and overlapping regions of the protein required for cell adhesion and for wingless signaling.
The Journal of cell biology - 1 Sept 1996
Orsulic S, Peifer M
Abstract excerpt
Armadillo, the Drosophila homologue of vertebrate beta-catenin, plays a pivotal role both in Wingless signaling and in assembly of adherens junctions. We performed the first in vivo structure-function study of an adherens junction protein, by generating and examining a series of Armadillo mutants...
Topics
- Alleles
- Animals
- Armadillo Domain Proteins
- Base Sequence
- Cadherins
- Cell Adhesion
- Cell Nucleus
- Cytoskeletal Proteins
- DNA
- Drosophila
- Drosophila Proteins
- Female
- Genetic Complementation Test
- Humans
- Insect Hormones
- Male
- Molecular Sequence Data
- Mutagenesis