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Article

CD44 regulates tight-junction assembly and barrier function.

The Journal of investigative dermatology - 1 Apr 2011

Kirschner Nina, Haftek Marek, Niessen Carien M, Behne Martin J, Furuse Mikio, Moll Ingrid, Brandner Johanna M

Abstract excerpt

Upon barrier disturbance, adult CD44 knockout (KO) mice show delayed recovery of epidermal barrier function. This correlates with the loss of apical polarization of lamellar body (LB) secretion. As tight junctions (TJs) are crucial for barrier function and regulate polarized targeting of vesicles, we hypothesized that CD44 regulates TJs and associated cell polarity complexes, which in turn contributes to altered...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21191420
DOI: 10.1038/jid.2010.390

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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