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Article

Human sympathetic activation by alpha2-adrenergic blockade with yohimbine: Bimodal, epistatic influence of cytochrome P450-mediated drug metabolism.

Clinical pharmacology and therapeutics - 1 Aug 2004

Le Corre Pascal, Parmer Robert J, Kailasam Mala T, Kennedy Brian P, Skaar Todd P, Ho Herbert, Leverge Roger, Smith Douglas W, Ziegler Michael G, Insel Paul A, Schork Nicholas J, Flockhart David A, O'connor Daniel T

Abstract excerpt

BACKGROUND: alpha2-Adrenergic blockade responses suggest adrenergic dysfunction in hypertension. alpha2-Blockade is also used to treat autonomic dysfunction. However, pharmacokinetic determinants of yohimbine disposition are not understood. METHODS: We evaluated alpha2-blockade with intravenous yohimbine in 172 individuals. Specific cytochrome P450 (CYP) isoform-mediated metabolism was investigated. Results were...

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Share to Cytochrome P-450 CYP2D6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP3A

Share to Cytochrome P-450 Enzyme System

Share to Infusions, Intravenous

Share to Metabolic Clearance Rate

Share to Receptors, Adrenergic, alpha-2

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Source

Identifiers

PMID: 15289791
DOI: 10.1016/j.clpt.2004.04.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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